Custom Therapeutic Peptide Synthesis

Poly(ADP-ribose) polymerase (PARP) enzymes play a crucial role in the cellular response to DNA damage. As a leading preclinical contract research organization (CRO), Alfa Cytology provides PARP peptide inhibitor development services for combating various diseases.

Introduction to Peptide Drug for Inhibiting PARP

By facilitating DNA repair processes, PARP is integral to maintaining genomic stability. However, overactivation of PARP can lead to tumorigenesis, making it a prime target for cancer therapies. Custom therapeutic peptides designed to inhibit PARP offer a novel approach in oncology, leveraging the specificity and potency that peptides can provide.

Fig. 1 Molecular mechanism of PARP1/2 in the DNA damage response. (Alhusaini A., et al. 2021)

Recent studies have demonstrated that synthetic peptides can effectively inhibit PARP activity, leading to enhanced cytotoxicity in cancer cells. For example, specific peptide inhibitors have shown promise in preclinical models, disrupting the interaction between PARP and DNA, thus preventing the repair of DNA breaks. This mechanism not only sensitizes cancer cells to conventional therapies but also highlights the potential of peptides in personalized medicine.

Our Services

At Alfa Cytology, we specialize in the custom synthesis of therapeutic peptides tailored for PARP inhibition. Our state-of-the-art facilities and expertise allow us to create high-purity peptides that meet rigorous quality standards for research and clinical applications.

Tailored Peptide Design

Custom Sequence Development

In collaboration with our clients, we develop specific peptide sequences that target PARP isoforms effectively. Our team applies bioinformatics tools to optimize these sequences for enhanced binding affinity and specificity.

Computational Modeling

Our design process incorporates advanced computational modeling techniques. These simulations help predict the structural and functional properties of the peptides, ensuring that the final products are optimized for their intended biological activity.

Modification and Optimization

We offer options for peptide modifications, including cyclization, incorporation of non-natural amino acids, and post-translational modifications. These enhancements can improve peptide stability, bioavailability, and resistance to enzymatic degradation.

High-Quality Synthesis

Our peptides undergo extensive quality control testing, including mass spectrometry and reverse-phase high-performance liquid chromatography (RP-HPLC). By adhering to these high standards in peptide synthesis, Alfa Cytology ensures that our clients receive reliable, high-quality products that advance their research in PARP inhibition and other therapeutic areas.

For more information about our custom therapeutic peptide synthesis services aimed at inhibiting PARP, please reach out to our team at Alfa Cytology. We are committed to advancing cancer research through innovative peptide solutions. your project needs.

For research use only. Not intended for any clinical use.