Therapeutic Cyclic Peptide Development

The development of therapeutic cyclic peptides marks a significant advancement in cancer therapy, especially in inhibiting PARP enzymes. These peptides offer greater selectivity, enhanced stability, and reduced toxicity compared to traditional PARP inhibitors, addressing key challenges in current treatments. Alfa Cytology offers development services for PARP cyclic peptide inhibitors to combat various diseases.

Introduction to PARP Cyclic Peptide Inhibitor

Traditional PARP inhibitors have predominantly been small molecules with notable drawbacks, including high toxicity and low specificity. This has led to a growing interest in the development of therapeutic cyclic peptides as a novel class of inhibitors. Cyclic peptides offer unique advantages, such as enhanced stability, specificity, and the ability to penetrate biological barriers effectively. By targeting PARP enzymes more selectively, cyclic peptides can mitigate the adverse effects associated with conventional therapies, providing a promising avenue for cancer treatment.

Fig. 1 The structures of PARP7, PARP12, and the cyclic heptapeptide. (Pan C., et al. 2022)

Our Services

At Alfa Cytology, our platform provides a full range of services for cyclic peptide drug development for PARP inhibition, from high-throughput screening and optimization to preclinical validation, to streamline the translation of these compounds from custom therapeutic peptide synthesis to peptide lead optimization.

Custom Synthesis of Cyclic Peptides

Types of Cyclic Peptides

• Disulfide Bond (Up to three)
• Click Chemistry
• Bicyclic Cyclic Peptide
• Staple Peptides
• Lactone

Key Technologies

• Computational Modeling and Design
• Automated Peptide Synthesis
• High-Performance Liquid Chromatography (HPLC)
• Mass Spectrometry for Characterization
• Biological Assays and Screening

Optimization of Cyclic Peptide Molecular Structure

At Alfa Cytology, we provide exceptional high-throughput peptide synthesis capabilities, perfectly suited for creating custom linear or cyclized peptide libraries in both microgram and milligram quantities. Our advanced peptide synthesizers, preparative HPLCs, and analytical systems enable us to deliver even the most complex peptide libraries efficiently and reliably. To discuss potential collaborative opportunities, please don't hesitate to contact us.

For research use only. Not intended for any clinical use.